Abstract:-:-
This paper explains the state of the art optical
coherence tomogra¬phy as an efficient diagnostic imaging tool for biomedical
applications. It reviews the basic theory and modes of operation together with
its applications and limitations. It also examines the various kinds of
in¬struments, which are employed in the whole apparatus, in addition to a
discussion on hardware and software methods to combat the sources of error.
Optical coherence tomography is a recent
technology that has gained momentum in the medical and research fields. Its use
and manipulation of light to view live tissues within the body in real time is
a suited to a wide variety of fields in the medical profession. Unlike most
other medical imaging techniques, optical coherence tomography has better
resolution, depth in penetration, and quality. Although optical coherence
tomography was initially geared towards ophthalmology, it had now expanded to
many other fields in medicine. Through new technological advancements, the OCT
had been increasingly improving its quality and resolution of imaging.
Introduction
Optical Coherence Tomography (OCT) is a ten-year
old imaging technique which has attracted the attention of scientists and
engineers greatly. This is mainly due to the fact that it has been the first
diagnostic imaging technique
which has extensively employed the coherent properties of light.
Types of OCT
There are also other types of OCT which are also
utilize light to produce imaging of tissue however they tend to include or vary
the components of the system to provide more emphasis and extract more
information from scans based on something specific from the sample. One of
these ideas is the Doppler OCT which looks from for frequency shifts in the
interference patterns which would show moving objects in the sample such as
blood cells. This is particularly interesting to ophthalmologists since
variations in blood flow can be causes of blindness, including diabetic retinapothy
and macular degeneration. In addition to Doppler OCT, researchers are also
looking into polarization which would measure the polarization of returning
light and interference fringes since this might be a way to image damage to
tissue such as nerve fibers, skin, and other connective tissues.
Applications of
OCT
The numerous applications that OCT can be used for
is remarkable. OCT has the potential to be used for a great number of medical
fields and applications however, cancer and heart disease are two of
the most pressing and promising areas of application The imaging from the
optical coherence tomography has the potential to improve the current
cardiovascular therapies and procedures such as stenting and balloon
angioplasty by means of providing vascular images in real time to guide stent
placement and balloon inflation. Since OCT has the capability of clearly
identifying plaques in the blood stream thus being able to differentiate
between stable plaques and unstable plaques, which are probably responsible for
up to seventy percent of all heart attacks, it aids those that suffer from
cardiac problems. In addition to helping those with cardiac problems, OCT can
also be valuable others.
Speed
As important as the resolution is the speed of an
OCT system. The frame rate is basically determined by the speed with which the
path-length could be swept, in order to obtain a complete cross correlation
function.
As a result, major effort has been put into faster
sweep of the time of flight difference between the reference and the sample
arms. Several methods have been used that a few of them will be introduced here
.
In early OCT systems the path-length in the
reference arm was changed by using a moving mirror or a galvanometer. This
method usually results in acquisition rate of less than 2 frames per second.
The second generation systems employed fiber
stretching or piezoelectric
crystals to modify the path-length of the reference arm. The limitations of
this technique are polarization mode dispersion, hysteresis, crystal
break¬down, and usually very high voltages.
A new technique has also been introduced recently
by the employment of grating-based phase control delay. The Fourier transform
is generated on the grating upon incidence of the reference beam. The scattered
wave is then directed to a linear wavelength dependent phase ramp, and since
linear phase ramp in the frequency domain stands
for group delay in time domain, when the signal is incident on the grating for
the second time, the inverse Fourier transform is
generated. In this way the group delay can be swept by tilting the mirror at different angles. This method provides frame
rates between 4 and 8. Moreover, it provides two other advantages, i.e., the
group delay can be swept independently from the phase delay, and the group
velocity dispersion could be varied without the employment of an extra prism.
Conclusions
Optical coherence tomography (OCT) has been
emerged a novel diagnostic tool for bio medical applications,
especially in situations where conventional imaging methods are either hazardous or of little valuable information. The continuing
success of OCT depends on the design and fabrication of cost effective as well
as portable ultra wide-band
light sources in order to pro¬vide better resolution.
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